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KMID : 1022820120030020038
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Journal of Multiple Sclerosis and Neuroimmunology
2012 Volume.3 No. 2 p.38 ~ p.46
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Overview of Rheumatologic Diseases Associated with Central Nervous System Involvement: Focusing on Sj?gren’s Syndrome, Antiphospholipid Antibody Syndrome, and Behcet’s Disease
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Ahn Joong-Kyong
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Abstract
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Systemic rheumatic diseases may have present with several neurologic manifestations. Central nervous manifestations certainly occur in various rheumatic diseases including systemic lupus erythematosus, Sj?gren’s syndrome. Neurologic manifestations in rheumatic diseases can be indistinguishable from an inflammatory demyelinating disease of the central nervous system (CNS) such as multiple sclerosis and neuromyelitis optica because of strikingly similar manifestations and no specific diagnostic tools. However, it is important to make differential diagnosis between rheumatic diseases with neurologic involvement and inflammatory CNS demyelinating diseases because of quite different treatment and prognosis. Thus, assessment for systemic rheumatic diseases should be included in all patients presenting with CNS demyelinating disease, and vice versa. We discuss here the clinical features, pathogenic mechanisms, laboratory findings and diagnosis of systemic rheumatic diseases associated with CNS involvement, focusing on Sj?gren’s syndrome, antiphospholipid antibody syndrome and Behcet’s disease.
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KEYWORD
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Sjogren’s syndrome, Antiphospholipid antibody syndrome, Behcet’s disease, Neurologic
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